The eye area is the thinnest, most fragile skin on the face — only about 0.5mm thick, lacking sebaceous glands and subcutaneous fat protection. Causes of periocular fine lines: (1) Aging — collagen and elastin loss in the eye area with age, skin thins and loses elasticity, fine lines appear first around the eyes. (2) Expression habits — blinking, squinting, and laughing repeatedly contract periocular muscles, dynamic lines gradually become static. (3) UV damage — thin eye skin means deeper UV damage, photoaging accelerates fine line formation. (4) Dryness — the eye area lacks sebaceous glands, prone to dryness that makes fine lines more visible. (5) Eye rubbing — frequent rubbing pulls the skin, accelerating fine lines. Types: (1) Dynamic lines — appear with expression (e.g., crow’s feet when smiling). (2) Static lines — visible without expression. (3) Under-eye lines — reticular fine lines in the under-eye area. Rappoel Dermatology near Gangnam Station, Seoul, uses Rejuran PDRN (Polydeoxyribonucleotide) injection — a regeneration agent extracted from salmon DNA, injected into the periocular dermis to stimulate collagen neogenesis, improving fine lines in 20 minutes.
Technical Advantages of Rejuran PDRN Eye Area Regeneration
- PDRN tissue regeneration mechanism: PDRN is polydeoxyribonucleotide extracted from salmon milt — after injection into the dermis, it activates A2A receptors, promoting fibroblast proliferation and collagen synthesis. Unlike HA’s ‘physical filling,’ PDRN is ‘biological regeneration’ — fundamentally restoring the skin’s collagen structure
- Eye-area micro-injection technique: Eye skin is extremely thin — Rappoel uses 34G ultra-fine needles (thinner than hair), performing multi-point micro-injections in the superficial dermis (0.01-0.02ml per point), precisely targeting fine line areas without damaging fragile eye skin
- Improves fine lines while brightening skin tone: PDRN not only promotes collagen regeneration to improve fine lines — it also improves periocular microcirculation, reducing pigmentation for brighter, more even eye-area skin tone
- High biocompatibility, no rejection: PDRN is structurally similar to human DNA — extremely high biocompatibility with virtually no allergic or rejection reactions. Salmon DNA is highly purified, with safety clinically validated
- Synergy with other treatments: PDRN works synergistically with Coretox (dynamic lines), HA (deep folds), and pico laser (pigmentation) — PDRN handles skin texture regeneration while other treatments address their respective concerns, optimal in combination
Treatment Strategies for Different Periocular Fine Lines
- Dynamic crow’s feet type: Radial fine lines at the eye corners when smiling or squinting. Strategy: Coretox periocular injection (6-12 units per side) to relax the orbicularis oculi + PDRN periocular injection (0.5ml per side) to improve static lines — Botox controls dynamic lines, PDRN regenerates skin texture
- Static crow’s feet type: Eye corner lines visible without expression. Strategy: PDRN periocular injection primarily (0.5-1.0ml per side), 3 sessions — PDRN stimulates collagen regeneration, fundamentally improving static lines
- Under-eye fine lines type: Reticular fine lines in the under-eye area, creasing with makeup. Strategy: PDRN under-eye micro-injection (0.3-0.5ml per side) — under-eye skin is extremely thin, requiring very gentle micro-injections, 3 sessions for visible improvement
- Comprehensive eye-area aging type: Fine lines + laxity + pigmentation + dryness simultaneously. Strategy: PDRN full periocular injection (0.5-1.0ml per side) + Coretox dynamic line control + pico laser pigmentation treatment — multi-modal approach
- Tear trough-related under-eye lines: Tear trough shadows make under-eye lines more visible. Strategy: PDRN under-eye injection (0.3-0.5ml per side) for fine lines + HA tear trough filler (0.3-0.5ml per side) for hollowness — fill hollowness first, then improve lines
Rappoel Rejuran PDRN Periocular Injection Treatment Protocol
- Eye area assessment and plan design (5 min): Frontal and side evaluation of fine line type (dynamic/static), under-eye state, pigmentation degree → check tear trough and eye bags → photograph → establish injection plan (volume, areas)
- Cleansing and anesthesia (10 min): Eye area makeup removal → alcohol swab disinfection → topical lidocaine cream for 15 minutes (thin eye skin absorbs anesthetic faster)
- Micro-injection (10 min): 34G ultra-fine needle → multi-point micro-injections in the superficial dermis of fine line areas → 0.01-0.02ml per point → total 0.5-1.0ml per side → gentle pressure after injection
- Post-treatment soothing and assessment (3 min): Cold compress → confirm no abnormal reaction → check injection evenness
- Post-care instructions (2 min): Precautions (avoid rubbing eyes and makeup for 24 hours, avoid strenuous exercise for 48 hours, avoid high-heat and acid-containing eye skincare for 1 week, strict sun protection) → schedule 4-week follow-up for second session
The Rejuran PDRN periocular injection takes about 20 minutes, with mild redness and pinholes subsiding in 1-2 days. 3 sessions (4 weeks apart) achieve optimal results. Located 3 minutes from Gangnam Station Exit 10, with seamless English and Chinese consultation.
Frequently Asked Questions
How long do Rejuran PDRN eye area results last? How many sessions are needed?
PDRN eye area results have two phases: (1) Initial effect — collagen begins regenerating 2-4 weeks after injection, fine lines gradually improve. (2) Cumulative effect — 3 sessions (4 weeks apart) achieve optimal results, lasting 6-9 months. Recommendation: 3 intensive sessions initially, then 1 maintenance every 6-9 months. Factors: (1) Age — younger patients have stronger collagen regeneration, longer-lasting. (2) Sun protection — UV accelerates collagen loss; strict protection extends results. (3) Skincare — peptide and vitamin C eye creams enhance results. Rappoel recommends 3 sessions as a complete course, with maintenance when results diminish.
What’s the difference between PDRN and HA eye area filler? How to choose?
They solve different problems: (1) PDRN — ‘biological regeneration,’ injected into the dermis to activate collagen synthesis, improving skin texture (fine lines, roughness, dullness). Results are progressive (2-4 weeks), suitable for periocular fine lines and texture. (2) HA — ‘physical filling,’ injected into hollow areas to restore volume, addressing structural hollowness (tear trough, hollowness). Results are instant, suitable for tear trough and eye-area hollowness. Choosing: (1) Fine lines primarily → PDRN. (2) Tear trough hollowness primarily → HA. (3) Both fine lines and hollowness → PDRN + HA combined — PDRN improves texture, HA fills hollowness, most complete results. Rappoel assesses during consultation.
Is PDRN eye area injection painful? Will it swell?
Pain is minimal — Rappoel’s pain control: (1) 34G ultra-fine needle — thinner than hair, feels like a mosquito bite. (2) Topical anesthesia — lidocaine cream for 15 minutes, greatly reducing discomfort. (3) Micro-injection — only 0.01-0.02ml per point, minimal pressure. Post-treatment reactions: (1) Redness — mild injection-site redness, 2-4 hours. (2) Pinholes — fine pinholes close in 1-2 days, barely visible. (3) Swelling — thin eye skin may have mild swelling, 1-2 days. (4) Bruising — some have mild bruising (especially under-eye), 3-5 days. Overall recovery 1-2 days, normal work the next day (minimal concealer sufficient).
What’s the difference between PDRN and Coretox for crow’s feet? Can they be done together?
They solve different problems: (1) Coretox — relaxes the orbicularis oculi, improving ‘dynamic lines’ (crow’s feet when smiling). Fast onset (2-3 days), lasting 3-5 months. (2) PDRN — stimulates collagen regeneration, improving ‘static lines’ (visible without expression) and skin texture. Progressive results (2-4 weeks), lasting 6-9 months. Combined treatment is optimal: Coretox controls dynamic lines (preventing expression from further deepening static lines) + PDRN regenerates skin to improve static lines — synergistic, comprehensive dynamic + static improvement. Rappoel recommends: patients with significant crow’s feet should get Coretox first to relax muscles, then PDRN 2 weeks later to regenerate skin — control the ‘external cause’ (muscle pulling) first, then repair the ‘internal cause’ (collagen loss).
What is PDRN? Is it safe? What are the side effects?
PDRN (Polydeoxyribonucleotide) is polydeoxyribonucleotide extracted from salmon milt — a highly purified DNA fragment. Safety: (1) Extremely high biocompatibility — salmon DNA is structurally similar to human DNA, causing no rejection. (2) Clinically validated — PDRN has over 10 years of clinical use in Korea and Europe with a good safety record. (3) Purification — multiple purification steps remove proteins and impurities, retaining only active DNA fragments. Common reactions: mild injection-site redness, swelling, pinholes (1-2 days). Rare: mild bruising (3-5 days). Severe side effects are extremely rare. Not suitable: those with fish allergy, pregnancy/breastfeeding, severe autoimmune disease. Rappoel confirms allergy history and health status before injection.
Periocular fine lines making your eyes look tired? Rappoel Rejuran PDRN eye regeneration — 20 minutes for firm, bright eye area!
📍 77, Seocho-daero, Seocho-gu, Seoul, South Korea
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