Rejuran Knee PDRN Treatment in Seoul: Reverse Aging, Roughness, and Dullness on Knee Skin



The knees are one of the body parts that most readily reveal age, yet they are often neglected. Knee skin, due to constant friction, minimal sebaceous glands, sun exposure, and repeated joint flexion, ages faster than facial skin — becoming rough, dull, dry, and lined. Rejuran Healer knee PDRN injection is currently one of the most sought-after body rejuvenation treatments at premium dermatology clinics in Seoul. Salmon DNA-extracted PDRN is injected into the dermal layer of the knees to repair damaged tissue at the cellular level and restore smooth, supple skin texture.

Why Does Knee Skin Age Fast?

  • Minimal Sebaceous Glands: The knee area has far fewer sebaceous glands than the face, resulting in poor natural moisturizing ability and tendency toward dryness and flaking
  • Constant Friction: Daily activities — wearing trousers, kneeling, exercising — repeatedly abrade the knee skin surface
  • Cumulative Sun Damage: Knees are often exposed to sunlight in summer; UV radiation accelerates collagen loss and hyperpigmentation
  • Joint Movement: Repeated knee flexion and extension stretches the skin, making elastic fibers more prone to rupture

How Does PDRN Improve Knee Skin?

  • Regenerative Repair: PDRN (Polydeoxyribonucleotide), extracted from salmon DNA, is a growth factor activator that triggers skin cell self-repair mechanisms
  • Collagen Regeneration: Stimulates fibroblast proliferation of collagen and elastin, restoring knee skin elasticity and firmness
  • Improves Roughness and Dullness: Promotes normal keratinocyte metabolism, fading hyperpigmentation and restoring even skin tone
  • Deep Hydration: PDRN forms a moisture-retaining grid structure within the dermis, locking in hydration from within

Rappoel Clinic’s Rejuran Knee Protocol

  1. Pre-Treatment Cleansing and Anesthesia: Disinfection of the knee area, topical numbing cream applied for approximately 20 minutes
  2. PDRN Injection: Ultra-fine needle used to evenly inject PDRN into the dermis of both knees in a grid pattern; the doctor concentrates on areas of visible hyperpigmentation and roughness
  3. Post-Treatment Care: Ice pack to reduce mild redness; avoid water contact and strenuous exercise for 24 hours
  4. Recommended Course: One session every 3-4 weeks, 3 sessions for a complete course; maintenance every 6 months thereafter

Ideal Candidates

  • Rough, dull, or hyperpigmented knee skin
  • Dry, flaky knees lacking luster
  • Visible fine lines and laxity around the knee joints
  • Love wearing skirts and shorts but feel self-conscious about knee appearance
  • Already take good care of facial skin and want to extend skincare to other body areas

Rappoel Clinic, located in Seoul’s Gangnam district, has board-certified dermatologists with extensive experience in Rejuran PDRN injection. Each treatment’s injection depth and density is customized based on the individual’s knee skin condition, ensuring even and natural-looking results. Bilateral knee treatment takes approximately 30 minutes with no downtime and no interruption to your travel itinerary.

Frequently Asked Questions

Is Rejuran knee injection painful?
Topical numbing cream effectively reduces discomfort. Most patients describe it as a mild pricking sensation that is entirely tolerable. The knee area actually has relatively fewer nerve endings than the face, making it less painful than facial injections.
How long until I see results from knee PDRN?
You will notice knees feeling smoother and more hydrated about 2-4 weeks after the first session. The full effect is best achieved after completing 3 sessions (spaced 3-4 weeks apart), with results lasting 6-12 months.
Can I wear trousers after the treatment?
Yes, but loose-fitting trousers are recommended on the treatment day to avoid friction. After 24 hours, normal clothing can be worn with no restrictions.
Are there side effects from Rejuran on the knees?
PDRN is highly biocompatible with human DNA, so allergic reactions are extremely rare. Mild redness and tiny needle marks may appear post-treatment but typically subside within hours to one day.
What is the difference between knee PDRN and laser treatment for knees?
Laser primarily addresses epidermal pigmentation and roughness, while PDRN works at the deep dermal level to repair cells and stimulate collagen production from the source. The two can be combined for more comprehensive improvement.

Get confidence to show your knees — Contact Rappoel Clinic Seoul

📍 77, Seocho-daero, Seocho-gu, Seoul, South Korea

🕐 Mon–Fri 10:00–19:00 · Sat 10:00–17:00

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