What Is Re2O Skin Regeneration Injection?
Re2O is a next-generation skin regeneration injectable that works by directly replenishing the skin’s ECM (Extracellular Matrix). Unlike traditional oral collagen supplements, Re2O delivers nutrients precisely to the target skin layer through injection, promoting the body’s own collagen production for true skin regeneration from the inside out.

Re2O is not a synthetic filler—it genuinely replenishes the ECM (extracellular matrix) that your skin needs, stimulating autologous collagen production rather than simply adding volume.
Why Injection Over Oral Collagen?
- Extremely low absorption: Oral collagen is broken down into amino acids during digestion—very little reaches the skin
- Precise delivery: Re2O is injected directly into the target skin layer—no nutrients wasted
- Activates regeneration: After ECM replenishment, skin cells gain an optimal microenvironment to produce new collagen
- Visible results: Improved skin radiance visible within 2–4 weeks post-treatment
Who Is Re2O For?
- Those with dry, rough skin that has lost elasticity
- Anyone wanting to improve skin texture and achieve a dewy glow
- People with visible fine lines or enlarged pores
- Those looking to slow down skin aging
- As a foundation treatment before or alongside laser, Botox, or fillers

The Rappoel Re2O Treatment Process
1. Skin Analysis: A professional dermatologist assesses your skin condition, ECM status, and personal needs.
2. Topical Anesthesia: Numbing cream applied for 20–30 minutes for maximum comfort.
3. Re2O Injection: Precise injection into the target layer using fine needles. Treatment takes approximately 20–30 minutes.
4. Post-Care: Normal makeup can be applied. We recommend extra hydration and sun protection on the day of treatment.

Can Re2O Be Combined with Other Treatments?
- Re2O + Laser Toning: Laser improves pigmentation and texture while Re2O boosts elasticity and radiance
- Re2O + Botox: Treat dynamic wrinkles while improving overall skin quality simultaneously
- Re2O + Thread Lift: Physical lifting combined with skin regeneration for comprehensive facial rejuvenation
Why Choose Rappoel for Re2O?
- Experienced dermatologists perform all assessments and injections personally
- Prime location in Seocho-gu, near Gangnam, Seoul
- Consultations available in Chinese and English
- Zero downtime—ideal for short medical tourism trips to Korea
Frequently Asked Questions
Contact Rappoel Dermatology Clinic
📍 77, Seocho-daero, Seocho-gu, Seoul, South Korea
🕐 Mon–Fri 10:00–19:00 · Sat 10:00–17:00
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