Rejuran (also called the ‘baby injection’) is Korea’s signature skin-regeneration procedure — a favorite maintenance treatment among many Korean celebrities and dermatologists themselves. Common skin-quality concerns share an underlying theme of ‘compromised skin barrier plus dermal aging’: (1) Repeated dryness and flaking — weak barrier function means skincare cannot retain moisture. (2) Enlarged pores — collagen loss and sebum imbalance weaken the support around pores, making them look larger. (3) Fine lines and roughness — reduced dermal collagen and elastin fibers coarsen skin texture and create fine lines. (4) Redness and sensitivity — after barrier damage, external irritants easily trigger flushing and stinging. (5) Acne scars and uneven pigmentation — weakened repair capacity after inflammation. Rejuran’s core ingredient is PN (Polynucleotide) — DNA fragments extracted from salmon sperm that, when injected into the dermis, activate fibroblast activity, stimulate collagen and elastin regeneration, and repair damaged skin tissue — upgrading from ‘surface hydration’ to ‘dermal repair and regeneration.’ Rappoel Dermatology near Gangnam Station, Seoul, provides Rejuran treatment.
Technical Principles of Rejuran
- PN polynucleotide core: PN is a highly purified DNA fragment from salmon sperm — structurally compatible with human DNA; once injected, it acts as a ‘cell repair signal’ activating fibroblasts to promote new collagen and elastin
- Direct dermal injection: Ultra-fine needles deliver PN straight into the dermis — reaching the root of the problem (rather than staying in the surface stratum corneum) for more direct repair
- Skin barrier restoration: PN promotes epidermal cell regeneration and intercellular lipid synthesis — once the barrier recovers, moisture retention improves and redness and sensitivity decrease
- Collagen renewal and texture remodeling: Cumulative treatment stimulates collagen production — support around pores recovers, skin thickness increases, and texture refines
- Anti-inflammatory and repair modulation: PN has anti-inflammatory properties that modulate inflammation in damaged skin — especially helpful for redness and the healing phase of acne scars
Common Rejuran Treatment Protocols
- Full-face foundational care (3 sessions advised): Full-face PN injection — improving overall texture, pores, and radiance. Strategy: every 3-4 weeks, 3 sessions complete a full course, then a maintenance session every 3-6 months
- Focused boosting (eye area/neck): Intensified injection for localized aging zones like eye-area fine lines and neck lines. Strategy: ultra-fine needles or device-assisted delivery to improve local wrinkles
- Rejuran plus skin booster (mesotherapy): PN regeneration plus HA deep hydration — a ‘repair first, then hydrate’ full skincare combination. Strategy: same session or alternating (common in Korean dermatology)
- Rejuran after laser (post-treatment repair): Skin is in a healing phase after laser — PN accelerates repair and reduces hyperpigmentation risk. Strategy: PN at 2-4 weeks after laser
- Different Rejuran formulations: Selecting the suitable version by skin condition (e.g., enhanced formulas with higher PN concentration or additional components). Strategy: physician assesses skin and chooses at consultation
Rappoel Rejuran Protocol
- Consultation and skin assessment (5 min): Review skin issues (pores/fine lines/redness/dryness) → confirm barrier state → discuss expectations → plan the number of sessions
- Cleansing and anesthesia (20 min): Makeup removal → topical anesthetic cream for 20 minutes (full-face injection needs adequate anesthesia for comfort)
- PN injection (15-20 min): Point or linear injections into the dermis with ultra-fine needles → even full-face coverage → physician adjusts depth and density by skin condition (reduced in sensitive zones)
- Soothing (5 min): Calming mask or ice pack to ease redness and swelling → apply repair skincare
- Post-care instructions (2 min): No makeup or water contact that day (depending on puncture marks) → normal skincare and makeup after 24-48 hours → boost moisture and sun protection for 1 week, avoid exfoliation and sauna → next session in 3-4 weeks
A Rejuran session takes about 30-40 minutes (including anesthesia); you can apply makeup normally the next day, texture improvement appears within 2-4 weeks, and a full course (3 sessions) lasts 6-12 months. Located 3 minutes from Gangnam Station Exit 10, with seamless English and Chinese consultation.
Frequently Asked Questions
What is Rejuran? How is it different from a skin booster (water injection)?
Core differences: (1) Rejuran’s ingredient — PN polynucleotide (salmon DNA fragments) works on ‘repair and regeneration’: activating fibroblasts, promoting collagen and elastin renewal, and repairing the skin barrier — addressing structural skin-quality problems. (2) Skin booster’s ingredient — mainly HA for ‘deep hydration’: locking moisture in the dermis for a dewy, luminous look — addressing dehydration. (3) Analogy — a skin booster is ‘watering the skin,’ while Rejuran is ‘fertilizing and rebuilding the soil’ — the former hydrates, the latter cultivates. (4) Result differences — skin booster gives an immediate dewy glow (1-3 months); Rejuran needs cumulative sessions and improves ‘constitutional’ issues like pores, texture, thickness, and barrier — with longer-lasting results. (5) In practice — Korean dermatology commonly combines both (Rejuran plus HA) for the synergistic effect of ‘repair plus hydration.’ (6) Rappoel recommends the best plan based on your main concern (dullness and dehydration → skin booster; pores, fine lines, barrier → Rejuran or both).
Is Rejuran safe? What is the ingredient? Are there side effects?
Safety explained: (1) Ingredient source — PN is DNA purified from salmon sperm, highly processed to remove protein impurities — structurally similar to human DNA with good biocompatibility; approved for years by Korea’s MFDS and used in many countries as a mature ingredient. (2) Allergy risk — theoretically those allergic to fish should be cautious; purified PN contains no allergenic proteins, and actual allergic reactions are extremely rare; Rappoel asks about allergy history before injection. (3) Common side effects — redness, mild bruising at puncture points, and small papules in some — usually fading within 2-5 days. (4) Rare side effects — infection (extremely rare with sterile technique) and nodules (possible with over-superficial high-volume injection; experienced physicians avoid this). (5) Safety advantage — PN is not a foreign filler and is naturally metabolized by the body; it contains no cross-linkers and has a strong long-term safety record. (6) Rappoel uses authentic certified Rejuran products, sterile technique, and experienced physicians for a safe procedure.
Does Rejuran hurt? Is anesthesia used?
Pain experience: (1) Sensation — full-face multi-point injection with varying sensitivity by zone: forehead and cheeks are less sensitive; eye and lip areas more so; most describe ‘mild stinging and soreness.’ (2) Anesthesia — 20 minutes of topical cream is standard and greatly reduces discomfort; sensitive patients can discuss stronger anesthesia. (3) Duration — the actual injection takes 15-20 minutes across dozens to hundreds of points — a ‘cumulative micro-sting’ rather than one sharp pain. (4) After — skin feels flushed and warm (like mild sunburn), fading within hours to 1-2 days; a few have mild swelling. (5) Tolerance — most complete it comfortably under topical anesthesia; pain-sensitive patients may opt for staged sessions or added soothing measures. (6) Rappoel prioritizes comfort — adequate anesthesia, fine needles, and smooth technique keep the procedure as easy as possible.
How many Rejuran sessions do I need? How often?
Session count explained: (1) Single session — one session already improves texture (radiance and hydration), but ‘constitutional’ improvements (pores, texture, thickness) require accumulation. (2) Recommended course — a full course is usually 3 sessions (every 3-4 weeks); by session 3, collagen renewal accumulates into clear, stable skin-quality improvement. (3) Maintenance — after a full course, a session every 3-6 months maintains results — skin maintenance is a ‘long-term investment’ like fitness. (4) Timeline — noticeable at 2-4 weeks after session 1 (glow and hydration); pores, fine lines, and thickness improve clearly after sessions 2-3; results last 6-12 months after the course. (5) By condition — young or mildly troubled skin may feel clear improvement after 2 sessions; visibly aged or severely damaged skin may need 4-5. (6) Rappoel plans personalized courses — assessing skin first, then advising the best number and interval of sessions.
How much does Rejuran cost? How is it priced?
Cost explained: (1) Pricing — Rejuran is priced by ‘formulation plus treatment area’ (e.g., full face, full face plus neck, focused boosting); different versions (standard/enhanced) have different prices. (2) Price range — Korea is Rejuran’s home country, so prices are friendlier than elsewhere; Rappoel offers reasonable transparent pricing quoted after consultation. (3) Factors — formulation, treatment area, whether combined with a skin booster or other treatments, and clinic promotions. (4) Course pricing — a full 3-session course usually comes with package discounts, more economical than single sessions. (5) Value comparison — versus spending on high-priced skincare with limited results, Rejuran directly improves skin structure from the dermis — more efficient as a ‘course mindset’ investment. (6) Rappoel’s principle — no pushing of unnecessary sessions; planning based on actual skin needs; for detailed pricing, book a free consultation.
Who is suitable for Rejuran? Who is not?
Suitable: (1) those with large pores and rough texture wanting fundamental improvement; (2) those with dry, poorly hydrating skin that absorbs skincare poorly; (3) early-aging skin with fine lines and lost elasticity and radiance; (4) those with redness, sensitivity, and barrier damage (Rejuran’s repair properties suit them especially); (5) those wanting faster repair and lower hyperpigmentation risk after laser or peel treatments; (6) skincare enthusiasts wanting regular ‘skin cultivation’ maintenance. Unsuitable or cautious: (1) pregnancy and breastfeeding (postpone — insufficient safety data); (2) active infection, severe acne, or skin disease in the area (treat first); (3) severe allergy to fish or DNA components (physician assessment); (4) autoimmune disease or immunosuppressant use (physician assessment); (5) bleeding disorders or anticoagulant use (evaluation needed); (6) severely aged skin expecting ‘one-session transformation’ — Rejuran accumulates over sessions and requires patience to complete the full course.
How long is the recovery after Rejuran? Will it be red or bruised?
Recovery timeline: (1) At injection — skin flushes and warms (sunburn-like); puncture marks are tiny (mostly ultra-fine needles or cannulas). (2) Day 1 — the peak of redness and swelling; avoid makeup that day and boost moisturizing repair; a few have small bruises at puncture points. (3) Days 2-3 — redness clearly subsides; most resume normal makeup and social life (some still slightly flushed). (4) Days 4-7 — skin returns to normal, and you begin to feel finer texture. (5) Weeks 2-4 — collagen renewal kicks in; texture improvement (glow, pores) becomes increasingly visible. (6) Bruising — small red dots at puncture sites are common but tiny, concealable with makeup, fading in 5-7 days; extent depends on constitution and physician technique. (7) Care notes — avoid exfoliation, acid peels, saunas, strenuous exercise, and sun exposure for 1 week (boost sun protection); avoid irritating skincare. (8) Social planning — most return to normal social life in 2-3 days; reserve a week before major events.
Can Rejuran be combined with other treatments?
Combination strategies: (1) Rejuran plus skin booster — the classic combo: PN repair and regeneration plus HA deep hydration, solving ‘repair and hydration’ together — common in Korean dermatology. (2) Rejuran plus pico/carbon laser — the laser first handles pigmentation or pores; Rejuran then accelerates skin regeneration during the healing phase, lowering hyperpigmentation and dryness risk — a complete destroy-then-repair cycle. (3) Rejuran plus botox — botox relaxes dynamic lines while Rejuran improves static texture — comprehensive handling of dynamic and static wrinkles. (4) Rejuran plus Thermage/ultrasound lifting — devices stimulate deep collagen contraction and remodeling while Rejuran supplies superficial repair nutrients — deep and superficial anti-aging in combination. (5) Rejuran plus HA filler — filler addresses local volume deficits while Rejuran improves overall skin quality — combining points and surface. (6) Sequencing — most combinations can be done in the same session or 1-2 weeks apart as the physician plans; Rappoel offers personalized ‘skin management programs’ planned in one visit.
What is the difference between Rejuran and collagen-stimulating fillers like Sculptra?
Ingredient comparison: (1) Rejuran (PN) — salmon DNA polynucleotide: promotes fibroblast activity and collagen renewal and repairs the barrier; focused on ‘improving skin quality’ with gradual, natural results requiring multiple sessions — Korea’s national-level maintenance injection. (2) Collagen-stimulating fillers (PLLA/PCL types) — poly-L-lactic acid or polycaprolactone microparticles: injected to trigger collagen encapsulation and growth, mainly for ‘filling depressions and volume’ — used for temples, nasolabial folds, and cheek hollows, with results lasting 1-2+ years. (3) Core difference — Rejuran is ‘whole-face skin cultivation’ (texture, pores, barrier, fine lines); these fillers are ‘localized volume restoration’ — different purposes and injection planes. (4) Can they be combined? — Yes: collagen stimulators fill depressions while Rejuran cultivates the whole face — but physician planning is needed to avoid overstimulation. (5) Cost differences — Rejuran requires multiple sessions (lower per-session cost, total depends on count); collagen stimulators cost more per session but last longer. (6) Rappoel recommends the best component combination based on whether your main concern is ‘skin quality’ or ‘volume loss.’
Will one Rejuran session improve my skin? When will I see results?
Result timeline: (1) Immediate after one session — skin looks dewy thanks to micro-trauma stimulation and the hydrating repair mask (partly temporary). (2) Weeks 1-2 — the barrier starts repairing; hydration and radiance improve and redness lessens. (3) Weeks 2-4 — collagen renewal begins; pores and skin feel start improving — the main perceivable effect of a single session. (4) After session 3 (about 3 months) — collagen accumulation reaches a tipping point — pores, fine lines, thickness, and elasticity show clear, stable improvement. (5) Maintenance — improvements persist for 6-12 months after the full course, gradually returning with natural aging. (6) Honest note — Rejuran is not a ‘one-shot skin swap’ magic but the science of ‘cumulative cultivation’; clear transformation requires completing the recommended course — Rappoel plans with a course mindset, not one-off sales. (7) Lifestyle support — adequate sleep, sun protection, and basic moisturizing amplify Rejuran’s results.
Large pores and fine lines aging your skin? Rappoel Rejuran — cultivate celebrity-grade skin from the dermis!
📍 77, Seocho-daero, Seocho-gu, Seoul, South Korea
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