Periocular Fine Lines Treatment in Seoul: Rejuran PDRN Eye Area Regeneration at Rappoel Dermatology Gangnam<\/title><br \/>\n<meta name=\"description\" content=\"Eye area fine lines making your eyes look tired and aged? PDRN injection stimulates collagen regeneration \u2014 Rappoel Dermatology 20 minutes to improve periocular fine lines for firm, bright eye skin\">\n<link rel=\"alternate\" hreflang=\"en\" href=\"https:\/\/rappoel-clinic.com\/rejuran-pdrn-periocular-fine-lines-en\/\" \/>\n<link rel=\"alternate\" hreflang=\"zh-TW\" href=\"https:\/\/rappoel-clinic.com\/rejuran-pdrn-periocular-fine-lines-zh\/\" \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"MedicalClinic\", \"@id\": \"https:\/\/rappoel-clinic.com\/#clinic\", \"name\": \"Rappoel Dermatology Clinic\", \"alternateName\": [\"Rappoel \u76ae\u819a\u79d1\", \"\ub77c\ud3ec\uc5d8 \ud53c\ubd80\uacfc\"], \"url\": \"https:\/\/rappoel-clinic.com\", \"address\": {\"@type\": \"PostalAddress\", \"streetAddress\": \"77, Seocho-daero\", \"addressLocality\": \"Seocho-gu\", \"addressRegion\": \"Seoul\", \"postalCode\": \"06609\", \"addressCountry\": \"KR\"}, \"geo\": {\"@type\": \"GeoCoordinates\", \"latitude\": 37.4926, \"longitude\": 127.0175}, \"telephone\": \"+82-2-XXXX-XXXX\", \"openingHours\": [\"Mo-Fr 10:00-19:00\", \"Sa 10:00-17:00\"], \"medicalSpecialty\": \"Dermatology\", \"availableService\": [{\"@type\": \"MedicalProcedure\", \"name\": \"Thread Lift (Aptos)\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Hyaluronic Acid Filler\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Botulinum Toxin (Botox)\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Ultherapy \/ HIFU\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Skin Booster (Juvelook \/ Exosomes)\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Laser Skin Treatment\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Onda Coolwaves Body Contouring\"}], \"sameAs\": [\"https:\/\/www.instagram.com\/rappoel_official\"]}<\/script><br \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"Article\", \"headline\": \"Periocular Fine Lines Treatment in Seoul: Rejuran PDRN Eye Area Regeneration at Rappoel Dermatology Gangnam\", \"description\": \"Eye area fine lines making your eyes look tired and aged? PDRN injection stimulates collagen regeneration \u2014 Rappoel Dermatology 20 minutes to improve periocular fine lines for firm, bright eye skin\", \"inLanguage\": \"en\", \"author\": {\"@type\": \"Organization\", \"name\": \"Rappoel Dermatology Clinic\"}, \"publisher\": {\"@type\": \"Organization\", \"name\": \"Rappoel Dermatology Clinic\", \"logo\": {\"@type\": \"ImageObject\", \"url\": \"https:\/\/rappoel-clinic.com\/wp-content\/uploads\/2026\/04\/favicon-512.png\"}}, \"about\": {\"@id\": \"https:\/\/rappoel-clinic.com\/#clinic\"}}<\/script><br \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"How long do Rejuran PDRN eye area results last? How many sessions are needed?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"PDRN eye area results have two phases: (1) Initial effect \u2014 collagen begins regenerating 2-4 weeks after injection, fine lines gradually improve. (2) Cumulative effect \u2014 3 sessions (4 weeks apart) achieve optimal results, lasting 6-9 months. Recommendation: 3 intensive sessions initially, then 1 maintenance every 6-9 months. Factors: (1) Age \u2014 younger patients have stronger collagen regeneration, longer-lasting. (2) Sun protection \u2014 UV accelerates collagen loss; strict protection extends results. (3) Skincare \u2014 peptide and vitamin C eye creams enhance results. Rappoel recommends 3 sessions as a complete course, with maintenance when results diminish.\"}}, {\"@type\": \"Question\", \"name\": \"What's the difference between PDRN and HA eye area filler? How to choose?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"They solve different problems: (1) PDRN \u2014 'biological regeneration,' injected into the dermis to activate collagen synthesis, improving skin texture (fine lines, roughness, dullness). Results are progressive (2-4 weeks), suitable for periocular fine lines and texture. (2) HA \u2014 'physical filling,' injected into hollow areas to restore volume, addressing structural hollowness (tear trough, hollowness). Results are instant, suitable for tear trough and eye-area hollowness. Choosing: (1) Fine lines primarily \u2192 PDRN. (2) Tear trough hollowness primarily \u2192 HA. (3) Both fine lines and hollowness \u2192 PDRN + HA combined \u2014 PDRN improves texture, HA fills hollowness, most complete results. Rappoel assesses during consultation.\"}}, {\"@type\": \"Question\", \"name\": \"Is PDRN eye area injection painful? Will it swell?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Pain is minimal \u2014 Rappoel's pain control: (1) 34G ultra-fine needle \u2014 thinner than hair, feels like a mosquito bite. (2) Topical anesthesia \u2014 lidocaine cream for 15 minutes, greatly reducing discomfort. (3) Micro-injection \u2014 only 0.01-0.02ml per point, minimal pressure. Post-treatment reactions: (1) Redness \u2014 mild injection-site redness, 2-4 hours. (2) Pinholes \u2014 fine pinholes close in 1-2 days, barely visible. (3) Swelling \u2014 thin eye skin may have mild swelling, 1-2 days. (4) Bruising \u2014 some have mild bruising (especially under-eye), 3-5 days. Overall recovery 1-2 days, normal work the next day (minimal concealer sufficient).\"}}, {\"@type\": \"Question\", \"name\": \"What's the difference between PDRN and Coretox for crow's feet? 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What are the side effects?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"PDRN (Polydeoxyribonucleotide) is polydeoxyribonucleotide extracted from salmon milt \u2014 a highly purified DNA fragment. Safety: (1) Extremely high biocompatibility \u2014 salmon DNA is structurally similar to human DNA, causing no rejection. (2) Clinically validated \u2014 PDRN has over 10 years of clinical use in Korea and Europe with a good safety record. (3) Purification \u2014 multiple purification steps remove proteins and impurities, retaining only active DNA fragments. Common reactions: mild injection-site redness, swelling, pinholes (1-2 days). Rare: mild bruising (3-5 days). Severe side effects are extremely rare. Not suitable: those with fish allergy, pregnancy\/breastfeeding, severe autoimmune disease. Rappoel confirms allergy history and health status before injection.\"}}]}<\/script><\/p>\n<style>\n*{box-sizing:border-box;margin:0;padding:0}\nbody{font-family:'PingFang SC','Noto Sans KR',sans-serif;background:#fffcf7;color:#3d2e1e;line-height:1.8}\n.wrap{max-width:677px;margin:0 auto;padding:32px 20px 60px}\n.banner{background:#FFF8EC;text-align:center;padding:36px 20px 28px;margin-bottom:36px;border-bottom:1px solid #e8d5c0}\n.banner-tag{font-size:11px;letter-spacing:3px;color:#8B7355;text-transform:uppercase;margin-bottom:12px}\n.banner h1{font-size:24px;color:#3d2e1e;line-height:1.4;margin-bottom:12px}\n.banner .sub{font-size:13px;color:#6b5240;line-height:1.7}\nh2{font-size:19px;color:#3d2e1e;margin:32px 0 14px;padding-bottom:8px;border-bottom:1px solid #e8d5c0}\nh3{font-size:16px;color:#3d2e1e;margin:22px 0 10px}\np{font-size:15px;color:#555;line-height:1.9;margin-bottom:14px}\n.highlight{background:#fff;border:1px solid #f0e8dc;border-left:3px solid #D4A574;padding:16px 20px;margin:22px 0;border-radius:0 6px 6px 0}\n.highlight p{margin:0;font-size:14px;color:#6b5240}\n.card{background:#F5E6C8;border:1px solid #e8d5c0;border-radius:8px;padding:18px 22px;margin:16px 0}\n.card-title{font-size:13px;font-weight:700;color:#3d2e1e;margin-bottom:6px}\n.card p{font-size:14px;margin:0}\n.faq-item{margin:14px 0;border-bottom:1px solid #f0e8dc;padding-bottom:14px}\n.faq-q{font-weight:700;color:#3d2e1e;font-size:15px;margin-bottom:6px}\n.faq-a{font-size:14px;color:#555;line-height:1.8}\n.cta{background:#F5E6C8;text-align:center;padding:32px 20px;margin-top:40px;border-radius:8px}\n.cta h3{font-size:17px;color:#3d2e1e;margin-bottom:8px}\n.cta p{font-size:13px;color:#6b5240;margin-bottom:4px}\nimg{max-width:100%;height:auto;display:block;margin:20px auto;border-radius:6px}\nul,ol{padding-left:22px;margin-bottom:14px}\nli{font-size:15px;color:#555;line-height:1.9;margin-bottom:4px}\n.schema-block{display:none}\n@media(max-width:600px){.wrap{padding:20px 14px 40px}.banner h1{font-size:20px}}\n<\/style>\n<p><\/head><br \/>\n<body><\/p>\n<div class=\"wrap\">\n<div class=\"banner\">\n<div class=\"banner-tag\">Skincare<\/div>\n<h1>Periocular Fine Lines Treatment in Seoul: Rejuran PDRN Eye Area Regeneration at Rappoel Dermatology Gangnam<\/h1>\n<div class=\"sub\">Eye area fine lines making your eyes look tired and aged? PDRN injection stimulates collagen regeneration \u2014 Rappoel Dermatology 20 minutes to improve periocular fine lines for firm, bright eye skin<\/div>\n<\/p><\/div>\n<p>The eye area is the thinnest, most fragile skin on the face \u2014 only about 0.5mm thick, lacking sebaceous glands and subcutaneous fat protection. Causes of periocular fine lines: (1) Aging \u2014 collagen and elastin loss in the eye area with age, skin thins and loses elasticity, fine lines appear first around the eyes. (2) Expression habits \u2014 blinking, squinting, and laughing repeatedly contract periocular muscles, dynamic lines gradually become static. (3) UV damage \u2014 thin eye skin means deeper UV damage, photoaging accelerates fine line formation. (4) Dryness \u2014 the eye area lacks sebaceous glands, prone to dryness that makes fine lines more visible. (5) Eye rubbing \u2014 frequent rubbing pulls the skin, accelerating fine lines. Types: (1) Dynamic lines \u2014 appear with expression (e.g., crow’s feet when smiling). (2) Static lines \u2014 visible without expression. (3) Under-eye lines \u2014 reticular fine lines in the under-eye area. Rappoel Dermatology near Gangnam Station, Seoul, uses Rejuran PDRN (Polydeoxyribonucleotide) injection \u2014 a regeneration agent extracted from salmon DNA, injected into the periocular dermis to stimulate collagen neogenesis, improving fine lines in 20 minutes.<\/p>\n<h2>Technical Advantages of Rejuran PDRN Eye Area Regeneration<\/h2>\n<ul>\n<li><strong>PDRN tissue regeneration mechanism:<\/strong> PDRN is polydeoxyribonucleotide extracted from salmon milt \u2014 after injection into the dermis, it activates A2A receptors, promoting fibroblast proliferation and collagen synthesis. Unlike HA’s ‘physical filling,’ PDRN is ‘biological regeneration’ \u2014 fundamentally restoring the skin’s collagen structure<\/li>\n<li><strong>Eye-area micro-injection technique:<\/strong> Eye skin is extremely thin \u2014 Rappoel uses 34G ultra-fine needles (thinner than hair), performing multi-point micro-injections in the superficial dermis (0.01-0.02ml per point), precisely targeting fine line areas without damaging fragile eye skin<\/li>\n<li><strong>Improves fine lines while brightening skin tone:<\/strong> PDRN not only promotes collagen regeneration to improve fine lines \u2014 it also improves periocular microcirculation, reducing pigmentation for brighter, more even eye-area skin tone<\/li>\n<li><strong>High biocompatibility, no rejection:<\/strong> PDRN is structurally similar to human DNA \u2014 extremely high biocompatibility with virtually no allergic or rejection reactions. Salmon DNA is highly purified, with safety clinically validated<\/li>\n<li><strong>Synergy with other treatments:<\/strong> PDRN works synergistically with Coretox (dynamic lines), HA (deep folds), and pico laser (pigmentation) \u2014 PDRN handles skin texture regeneration while other treatments address their respective concerns, optimal in combination<\/li>\n<\/ul>\n<h2>Treatment Strategies for Different Periocular Fine Lines<\/h2>\n<ul>\n<li><strong>Dynamic crow’s feet type:<\/strong> Radial fine lines at the eye corners when smiling or squinting. Strategy: Coretox periocular injection (6-12 units per side) to relax the orbicularis oculi + PDRN periocular injection (0.5ml per side) to improve static lines \u2014 Botox controls dynamic lines, PDRN regenerates skin texture<\/li>\n<li><strong>Static crow’s feet type:<\/strong> Eye corner lines visible without expression. Strategy: PDRN periocular injection primarily (0.5-1.0ml per side), 3 sessions \u2014 PDRN stimulates collagen regeneration, fundamentally improving static lines<\/li>\n<li><strong>Under-eye fine lines type:<\/strong> Reticular fine lines in the under-eye area, creasing with makeup. Strategy: PDRN under-eye micro-injection (0.3-0.5ml per side) \u2014 under-eye skin is extremely thin, requiring very gentle micro-injections, 3 sessions for visible improvement<\/li>\n<li><strong>Comprehensive eye-area aging type:<\/strong> Fine lines + laxity + pigmentation + dryness simultaneously. Strategy: PDRN full periocular injection (0.5-1.0ml per side) + Coretox dynamic line control + pico laser pigmentation treatment \u2014 multi-modal approach<\/li>\n<li><strong>Tear trough-related under-eye lines:<\/strong> Tear trough shadows make under-eye lines more visible. Strategy: PDRN under-eye injection (0.3-0.5ml per side) for fine lines + HA tear trough filler (0.3-0.5ml per side) for hollowness \u2014 fill hollowness first, then improve lines<\/li>\n<\/ul>\n<h2>Rappoel Rejuran PDRN Periocular Injection Treatment Protocol<\/h2>\n<ol>\n<li><strong>Eye area assessment and plan design (5 min):<\/strong> Frontal and side evaluation of fine line type (dynamic\/static), under-eye state, pigmentation degree \u2192 check tear trough and eye bags \u2192 photograph \u2192 establish injection plan (volume, areas)<\/li>\n<li><strong>Cleansing and anesthesia (10 min):<\/strong> Eye area makeup removal \u2192 alcohol swab disinfection \u2192 topical lidocaine cream for 15 minutes (thin eye skin absorbs anesthetic faster)<\/li>\n<li><strong>Micro-injection (10 min):<\/strong> 34G ultra-fine needle \u2192 multi-point micro-injections in the superficial dermis of fine line areas \u2192 0.01-0.02ml per point \u2192 total 0.5-1.0ml per side \u2192 gentle pressure after injection<\/li>\n<li><strong>Post-treatment soothing and assessment (3 min):<\/strong> Cold compress \u2192 confirm no abnormal reaction \u2192 check injection evenness<\/li>\n<li><strong>Post-care instructions (2 min):<\/strong> Precautions (avoid rubbing eyes and makeup for 24 hours, avoid strenuous exercise for 48 hours, avoid high-heat and acid-containing eye skincare for 1 week, strict sun protection) \u2192 schedule 4-week follow-up for second session<\/li>\n<\/ol>\n<p>The Rejuran PDRN periocular injection takes about 20 minutes, with mild redness and pinholes subsiding in 1-2 days. 3 sessions (4 weeks apart) achieve optimal results. Located 3 minutes from Gangnam Station Exit 10, with seamless English and Chinese consultation.<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<div class=\"faq-item\">\n<div class=\"faq-q\">How long do Rejuran PDRN eye area results last? How many sessions are needed?<\/div>\n<div class=\"faq-a\">PDRN eye area results have two phases: (1) Initial effect \u2014 collagen begins regenerating 2-4 weeks after injection, fine lines gradually improve. (2) Cumulative effect \u2014 3 sessions (4 weeks apart) achieve optimal results, lasting 6-9 months. Recommendation: 3 intensive sessions initially, then 1 maintenance every 6-9 months. Factors: (1) Age \u2014 younger patients have stronger collagen regeneration, longer-lasting. (2) Sun protection \u2014 UV accelerates collagen loss; strict protection extends results. (3) Skincare \u2014 peptide and vitamin C eye creams enhance results. Rappoel recommends 3 sessions as a complete course, with maintenance when results diminish.<\/div>\n<\/div>\n<div class=\"faq-item\">\n<div class=\"faq-q\">What’s the difference between PDRN and HA eye area filler? How to choose?<\/div>\n<div class=\"faq-a\">They solve different problems: (1) PDRN \u2014 ‘biological regeneration,’ injected into the dermis to activate collagen synthesis, improving skin texture (fine lines, roughness, dullness). Results are progressive (2-4 weeks), suitable for periocular fine lines and texture. (2) HA \u2014 ‘physical filling,’ injected into hollow areas to restore volume, addressing structural hollowness (tear trough, hollowness). Results are instant, suitable for tear trough and eye-area hollowness. Choosing: (1) Fine lines primarily \u2192 PDRN. (2) Tear trough hollowness primarily \u2192 HA. (3) Both fine lines and hollowness \u2192 PDRN + HA combined \u2014 PDRN improves texture, HA fills hollowness, most complete results. Rappoel assesses during consultation.<\/div>\n<\/div>\n<div class=\"faq-item\">\n<div class=\"faq-q\">Is PDRN eye area injection painful? Will it swell?<\/div>\n<div class=\"faq-a\">Pain is minimal \u2014 Rappoel’s pain control: (1) 34G ultra-fine needle \u2014 thinner than hair, feels like a mosquito bite. (2) Topical anesthesia \u2014 lidocaine cream for 15 minutes, greatly reducing discomfort. (3) Micro-injection \u2014 only 0.01-0.02ml per point, minimal pressure. Post-treatment reactions: (1) Redness \u2014 mild injection-site redness, 2-4 hours. (2) Pinholes \u2014 fine pinholes close in 1-2 days, barely visible. (3) Swelling \u2014 thin eye skin may have mild swelling, 1-2 days. (4) Bruising \u2014 some have mild bruising (especially under-eye), 3-5 days. Overall recovery 1-2 days, normal work the next day (minimal concealer sufficient).<\/div>\n<\/div>\n<div class=\"faq-item\">\n<div class=\"faq-q\">What’s the difference between PDRN and Coretox for crow’s feet? Can they be done together?<\/div>\n<div class=\"faq-a\">They solve different problems: (1) Coretox \u2014 relaxes the orbicularis oculi, improving ‘dynamic lines’ (crow’s feet when smiling). Fast onset (2-3 days), lasting 3-5 months. (2) PDRN \u2014 stimulates collagen regeneration, improving ‘static lines’ (visible without expression) and skin texture. Progressive results (2-4 weeks), lasting 6-9 months. Combined treatment is optimal: Coretox controls dynamic lines (preventing expression from further deepening static lines) + PDRN regenerates skin to improve static lines \u2014 synergistic, comprehensive dynamic + static improvement. Rappoel recommends: patients with significant crow’s feet should get Coretox first to relax muscles, then PDRN 2 weeks later to regenerate skin \u2014 control the ‘external cause’ (muscle pulling) first, then repair the ‘internal cause’ (collagen loss).<\/div>\n<\/div>\n<div class=\"faq-item\">\n<div class=\"faq-q\">What is PDRN? Is it safe? What are the side effects?<\/div>\n<div class=\"faq-a\">PDRN (Polydeoxyribonucleotide) is polydeoxyribonucleotide extracted from salmon milt \u2014 a highly purified DNA fragment. Safety: (1) Extremely high biocompatibility \u2014 salmon DNA is structurally similar to human DNA, causing no rejection. (2) Clinically validated \u2014 PDRN has over 10 years of clinical use in Korea and Europe with a good safety record. (3) Purification \u2014 multiple purification steps remove proteins and impurities, retaining only active DNA fragments. Common reactions: mild injection-site redness, swelling, pinholes (1-2 days). Rare: mild bruising (3-5 days). Severe side effects are extremely rare. Not suitable: those with fish allergy, pregnancy\/breastfeeding, severe autoimmune disease. Rappoel confirms allergy history and health status before injection.<\/div>\n<\/div>\n<div class=\"cta\">\n<h3>Periocular fine lines making your eyes look tired? Rappoel Rejuran PDRN eye regeneration \u2014 20 minutes for firm, bright eye area!<\/h3>\n<p>\ud83d\udccd 77, Seocho-daero, Seocho-gu, Seoul, South Korea<\/p>\n<p>\ud83d\udd50 Mon\u2013Fri 10:00\u201319:00 \u00b7 Sat 10:00\u201317:00<\/p>\n<p>\ud83d\udcac WeChat Main: rappoelkr | WeChat Backup: rappoelkr2 | LINE: rappoelkr<\/p>\n<p style=\"margin-top:16px;font-size:13px;color:#8B7355;\">Scan to connect with us<\/p>\n<div style=\"display:flex;justify-content:center;gap:16px;flex-wrap:wrap;margin-top:10px;\">\n<div style=\"text-align:center;\">\n <img decoding=\"async\" src=\"https:\/\/rappoel-clinic.com\/wp-content\/uploads\/2026\/04\/Rappoel\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff08\u4e3b\u53f7\uff09-1.png\" alt=\"WeChat Main QR Code\" style=\"width:120px;height:120px;border-radius:6px;\" \/><\/p>\n<p style=\"font-size:11px;color:#6b5240;margin-top:4px;\">WeChat (Main)<\/p>\n<\/p><\/div>\n<div style=\"text-align:center;\">\n <img decoding=\"async\" src=\"https:\/\/rappoel-clinic.com\/wp-content\/uploads\/2026\/04\/Rappoel\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff08\u5907\u7528\u53f7\uff09-1.png\" alt=\"WeChat Backup QR Code\" style=\"width:120px;height:120px;border-radius:6px;\" \/><\/p>\n<p style=\"font-size:11px;color:#6b5240;margin-top:4px;\">WeChat (Backup)<\/p>\n<\/p><\/div>\n<div style=\"text-align:center;\">\n <img decoding=\"async\" src=\"https:\/\/rappoel-clinic.com\/wp-content\/uploads\/2026\/04\/Line\u4e8c\u7ef4\u7801-1.jpg\" alt=\"LINE QR Code\" style=\"width:120px;height:120px;border-radius:6px;\" \/><\/p>\n<p style=\"font-size:11px;color:#6b5240;margin-top:4px;\">LINE<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eye area fine lines making your eyes look tired and aged? 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\nPeriocular Fine Lines Treatment in Seoul: Rejuran PDRN Eye Area Regeneration at Rappoel Dermatology Gangnam<\/title><br \/>\n<meta name=\"description\" content=\"Eye area fine lines making your eyes look tired and aged? PDRN injection stimulates collagen regeneration \u2014 Rappoel Dermatology 20 minutes to improve periocular fine lines for firm, bright eye skin\">\n<link rel=\"alternate\" hreflang=\"en\" href=\"https:\/\/rappoel-clinic.com\/rejuran-pdrn-periocular-fine-lines-en\/\" \/>\n<link rel=\"alternate\" hreflang=\"zh-TW\" href=\"https:\/\/rappoel-clinic.com\/rejuran-pdrn-periocular-fine-lines-zh\/\" \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"MedicalClinic\", \"@id\": \"https:\/\/rappoel-clinic.com\/#clinic\", \"name\": \"Rappoel Dermatology Clinic\", \"alternateName\": [\"Rappoel \u76ae\u819a\u79d1\", \"\ub77c\ud3ec\uc5d8 \ud53c\ubd80\uacfc\"], \"url\": \"https:\/\/rappoel-clinic.com\", \"address\": {\"@type\": \"PostalAddress\", \"streetAddress\": \"77, Seocho-daero\", \"addressLocality\": \"Seocho-gu\", \"addressRegion\": \"Seoul\", \"postalCode\": \"06609\", \"addressCountry\": \"KR\"}, \"geo\": {\"@type\": \"GeoCoordinates\", \"latitude\": 37.4926, \"longitude\": 127.0175}, \"telephone\": \"+82-2-XXXX-XXXX\", \"openingHours\": [\"Mo-Fr 10:00-19:00\", \"Sa 10:00-17:00\"], \"medicalSpecialty\": \"Dermatology\", \"availableService\": [{\"@type\": \"MedicalProcedure\", \"name\": \"Thread Lift (Aptos)\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Hyaluronic Acid Filler\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Botulinum Toxin (Botox)\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Ultherapy \/ HIFU\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Skin Booster (Juvelook \/ Exosomes)\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Laser Skin Treatment\"}, {\"@type\": \"MedicalProcedure\", \"name\": \"Onda Coolwaves Body Contouring\"}], \"sameAs\": [\"https:\/\/www.instagram.com\/rappoel_official\"]}<\/script><br \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"Article\", \"headline\": \"Periocular Fine Lines Treatment in Seoul: Rejuran PDRN Eye Area Regeneration at Rappoel Dermatology Gangnam\", \"description\": \"Eye area fine lines making your eyes look tired and aged? PDRN injection stimulates collagen regeneration \u2014 Rappoel Dermatology 20 minutes to improve periocular fine lines for firm, bright eye skin\", \"inLanguage\": \"en\", \"author\": {\"@type\": \"Organization\", \"name\": \"Rappoel Dermatology Clinic\"}, \"publisher\": {\"@type\": \"Organization\", \"name\": \"Rappoel Dermatology Clinic\", \"logo\": {\"@type\": \"ImageObject\", \"url\": \"https:\/\/rappoel-clinic.com\/wp-content\/uploads\/2026\/04\/favicon-512.png\"}}, \"about\": {\"@id\": \"https:\/\/rappoel-clinic.com\/#clinic\"}}<\/script><br \/>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"How long do Rejuran PDRN eye area results last? How many sessions are needed?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"PDRN eye area results have two phases: (1) Initial effect \u2014 collagen begins regenerating 2-4 weeks after injection, fine lines gradually improve. (2) Cumulative effect \u2014 3 sessions (4 weeks apart) achieve optimal results, lasting 6-9 months. Recommendation: 3 intensive sessions initially, then 1 maintenance every 6-9 months. Factors: (1) Age \u2014 younger patients have stronger collagen regeneration, longer-lasting. (2) Sun protection \u2014 UV accelerates collagen loss; strict protection extends results. (3) Skincare \u2014 peptide and vitamin C eye creams enhance results. Rappoel recommends 3 sessions as a complete course, with maintenance when results diminish.\"}}, {\"@type\": \"Question\", \"name\": \"What's the difference between PDRN and HA eye area filler? How to choose?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"They solve different problems: (1) PDRN \u2014 'biological regeneration,' injected into the dermis to activate collagen synthesis, improving skin texture (fine lines, roughness, dullness). Results are progressive (2-4 weeks), suitable for periocular fine lines and texture. (2) HA \u2014 'physical filling,' injected into hollow areas to restore volume, addressing structural hollowness (tear trough, hollowness). Results are instant, suitable for tear trough and eye-area hollowness. Choosing: (1) Fine lines primarily \u2192 PDRN. (2) Tear trough hollowness primarily \u2192 HA. (3) Both fine lines and hollowness \u2192 PDRN + HA combined \u2014 PDRN improves texture, HA fills hollowness, most complete results. Rappoel assesses during consultation.\"}}, {\"@type\": \"Question\", \"name\": \"Is PDRN eye area injection painful? Will it swell?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Pain is minimal \u2014 Rappoel's pain control: (1) 34G ultra-fine needle \u2014 thinner than hair, feels like a mosquito bite. (2) Topical anesthesia \u2014 lidocaine cream for 15 minutes, greatly reducing discomfort. (3) Micro-injection \u2014 only 0.01-0.02ml per point, minimal pressure. Post-treatment reactions: (1) Redness \u2014 mild injection-site redness, 2-4 hours. (2) Pinholes \u2014 fine pinholes close in 1-2 days, barely visible. (3) Swelling \u2014 thin eye skin may have mild swelling, 1-2 days. (4) Bruising \u2014 some have mild bruising (especially under-eye), 3-5 days. Overall recovery 1-2 days, normal work the next day (minimal concealer sufficient).\"}}, {\"@type\": \"Question\", \"name\": \"What's the difference between PDRN and Coretox for crow's feet? Can they be done together?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"They solve different problems: (1) Coretox \u2014 relaxes the orbicularis oculi, improving 'dynamic lines' (crow's feet when smiling). Fast onset (2-3 days), lasting 3-5 months. (2) PDRN \u2014 stimulates collagen regeneration, improving 'static lines' (visible without expression) and skin texture. Progressive results (2-4 weeks), lasting 6-9 months. Combined treatment is optimal: Coretox controls dynamic lines (preventing expression from further deepening static lines) + PDRN regenerates skin to improve static lines \u2014 synergistic, comprehensive dynamic + static improvement. Rappoel recommends: patients with significant crow's feet should get Coretox first to relax muscles, then PDRN 2 weeks later to regenerate skin \u2014 control the 'external cause' (muscle pulling) first, then repair the 'internal cause' (collagen loss).\"}}, {\"@type\": \"Question\", \"name\": \"What is PDRN? Is it safe? What are the side effects?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"PDRN (Polydeoxyribonucleotide) is polydeoxyribonucleotide extracted from salmon milt \u2014 a highly purified DNA fragment. Safety: (1) Extremely high biocompatibility \u2014 salmon DNA is structurally similar to human DNA, causing no rejection. (2) Clinically validated \u2014 PDRN has over 10 years of clinical use in Korea and Europe with a good safety record. (3) Purification \u2014 multiple purification steps remove proteins and impurities, retaining only active DNA fragments. Common reactions: mild injection-site redness, swelling, pinholes (1-2 days). Rare: mild bruising (3-5 days). Severe side effects are extremely rare. Not suitable: those with fish allergy, pregnancy\/breastfeeding, severe autoimmune disease. Rappoel confirms allergy history and health status before injection.\"}}]}<\/script><\/p>\n<style>\n*{box-sizing:border-box;margin:0;padding:0}\nbody{font-family:'PingFang SC','Noto Sans KR',sans-serif;background:#fffcf7;color:#3d2e1e;line-height:1.8}\n.wrap{max-width:677px;margin:0 auto;padding:32px 20px 60px}\n.banner{background:#FFF8EC;text-align:center;padding:36px 20px 28px;margin-bottom:36px;border-bottom:1px solid #e8d5c0}\n.banner-tag{font-size:11px;letter-spacing:3px;color:#8B7355;text-transform:uppercase;margin-bottom:12px}\n.banner h1{font-size:24px;color:#3d2e1e;line-height:1.4;margin-bottom:12px}\n.banner .sub{font-size:13px;color:#6b5240;line-height:1.7}\nh2{font-size:19px;color:#3d2e1e;margin:32px 0 14px;padding-bottom:8px;border-bottom:1px solid #e8d5c0}\nh3{font-size:16px;color:#3d2e1e;margin:22px 0 10px}\np{font-size:15px;color:#555;line-height:1.9;margin-bottom:14px}\n.highlight{background:#fff;border:1px solid #f0e8dc;border-left:3px solid #D4A574;padding:16px 20px;margin:22px 0;border-radius:0 6px 6px 0}\n.highlight p{margin:0;font-size:14px;color:#6b5240}\n.card{background:#F5E6C8;border:1px solid #e8d5c0;border-radius:8px;padding:18px 22px;margin:16px 0}\n.card-title{font-size:13px;font-weight:700;color:#3d2e1e;margin-bottom:6px}\n.card p{font-size:14px;margin:0}\n.faq-item{margin:14px 0;border-bottom:1px solid #f0e8dc;padding-bottom:14px}\n.faq-q{font-weight:700;color:#3d2e1e;font-size:15px;margin-bottom:6px}\n.faq-a{font-size:14px;color:#555;line-height:1.8}\n.cta{background:#F5E6C8;text-align:center;padding:32px 20px;margin-top:40px;border-radius:8px}\n.cta h3{font-size:17px;color:#3d2e1e;margin-bottom:8px}\n.cta p{font-size:13px;color:#6b5240;margin-bottom:4px}\nimg{max-width:100%;height:auto;display:block;margin:20px auto;border-radius:6px}\nul,ol{padding-left:22px;margin-bottom:14px}\nli{font-size:15px;color:#555;line-height:1.9;margin-bottom:4px}\n.schema-block{display:none}\n@media(max-width:600px){.wrap{padding:20px 14px 40px}.banner h1{font-size:20px}}\n<\/style>\n<p><\/head><br \/>\n<body><\/p>\n<div class=\"wrap\">\n<div class=\"banner\">\n<div class=\"banner-tag\">Skincare<\/div>\n<h1>Periocular Fine Lines Treatment in Seoul: Rejuran PDRN Eye Area Regeneration at Rappoel Dermatology Gangnam<\/h1>\n<div class=\"sub\">Eye area fine lines making your eyes look tired and aged? PDRN injection stimulates collagen regeneration \u2014 Rappoel Dermatology 20 minutes to improve periocular fine lines for firm, bright eye skin<\/div>\n<\/p><\/div>\n<p>The eye area is the thinnest, most fragile skin on the face \u2014 only about 0.5mm thick, lacking sebaceous glands and subcutaneous fat protection. Causes of periocular fine lines: (1) Aging \u2014 collagen and elastin loss in the eye area with age, skin thins and loses elasticity, fine lines appear first around the eyes. (2) Expression habits \u2014 blinking, squinting, and laughing repeatedly contract periocular muscles, dynamic lines gradually become static. (3) UV damage \u2014 thin eye skin means deeper UV damage, photoaging accelerates fine line formation. (4) Dryness \u2014 the eye area lacks sebaceous glands, prone to dryness that makes fine lines more visible. (5) Eye rubbing \u2014 frequent rubbing pulls the skin, accelerating fine lines. Types: (1) Dynamic lines \u2014 appear with expression (e.g., crow’s feet when smiling). (2) Static lines \u2014 visible without expression. (3) Under-eye lines \u2014 reticular fine lines in the under-eye area. Rappoel Dermatology near Gangnam Station, Seoul, uses Rejuran PDRN (Polydeoxyribonucleotide) injection \u2014 a regeneration agent extracted from salmon DNA, injected into the periocular dermis to stimulate collagen neogenesis, improving fine lines in 20 minutes.<\/p>\n<h2>Technical Advantages of Rejuran PDRN Eye Area Regeneration<\/h2>\n<ul>\n<li><strong>PDRN tissue regeneration mechanism:<\/strong> PDRN is polydeoxyribonucleotide extracted from salmon milt \u2014 after injection into the dermis, it activates A2A receptors, promoting fibroblast proliferation and collagen synthesis. Unlike HA’s ‘physical filling,’ PDRN is ‘biological regeneration’ \u2014 fundamentally restoring the skin’s collagen structure<\/li>\n<li><strong>Eye-area micro-injection technique:<\/strong> Eye skin is extremely thin \u2014 Rappoel uses 34G ultra-fine needles (thinner than hair), performing multi-point micro-injections in the superficial dermis (0.01-0.02ml per point), precisely targeting fine line areas without damaging fragile eye skin<\/li>\n<li><strong>Improves fine lines while brightening skin tone:<\/strong> PDRN not only promotes collagen regeneration to improve fine lines \u2014 it also improves periocular microcirculation, reducing pigmentation for brighter, more even eye-area skin tone<\/li>\n<li><strong>High biocompatibility, no rejection:<\/strong> PDRN is structurally similar to human DNA \u2014 extremely high biocompatibility with virtually no allergic or rejection reactions. Salmon DNA is highly purified, with safety clinically validated<\/li>\n<li><strong>Synergy with other treatments:<\/strong> PDRN works synergistically with Coretox (dynamic lines), HA (deep folds), and pico laser (pigmentation) \u2014 PDRN handles skin texture regeneration while other treatments address their respective concerns, optimal in combination<\/li>\n<\/ul>\n<h2>Treatment Strategies for Different Periocular Fine Lines<\/h2>\n<ul>\n<li><strong>Dynamic crow’s feet type:<\/strong> Radial fine lines at the eye corners when smiling or squinting. Strategy: Coretox periocular injection (6-12 units per side) to relax the orbicularis oculi + PDRN periocular injection (0.5ml per side) to improve static lines \u2014 Botox controls dynamic lines, PDRN regenerates skin texture<\/li>\n<li><strong>Static crow’s feet type:<\/strong> Eye corner lines visible without expression. Strategy: PDRN periocular injection primarily (0.5-1.0ml per side), 3 sessions \u2014 PDRN stimulates collagen regeneration, fundamentally improving static lines<\/li>\n<li><strong>Under-eye fine lines type:<\/strong> Reticular fine lines in the under-eye area, creasing with makeup. Strategy: PDRN under-eye micro-injection (0.3-0.5ml per side) \u2014 under-eye skin is extremely thin, requiring very gentle micro-injections, 3 sessions for visible improvement<\/li>\n<li><strong>Comprehensive eye-area aging type:<\/strong> Fine lines + laxity + pigmentation + dryness simultaneously. Strategy: PDRN full periocular injection (0.5-1.0ml per side) + Coretox dynamic line control + pico laser pigmentation treatment \u2014 multi-modal approach<\/li>\n<li><strong>Tear trough-related under-eye lines:<\/strong> Tear trough shadows make under-eye lines more visible. Strategy: PDRN under-eye injection (0.3-0.5ml per side) for fine lines + HA tear trough filler (0.3-0.5ml per side) for hollowness \u2014 fill hollowness first, then improve lines<\/li>\n<\/ul>\n<h2>Rappoel Rejuran PDRN Periocular Injection Treatment Protocol<\/h2>\n<ol>\n<li><strong>Eye area assessment and plan design (5 min):<\/strong> Frontal and side evaluation of fine line type (dynamic\/static), under-eye state, pigmentation degree \u2192 check tear trough and eye bags \u2192 photograph \u2192 establish injection plan (volume, areas)<\/li>\n<li><strong>Cleansing and anesthesia (10 min):<\/strong> Eye area makeup removal \u2192 alcohol swab disinfection \u2192 topical lidocaine cream for 15 minutes (thin eye skin absorbs anesthetic faster)<\/li>\n<li><strong>Micro-injection (10 min):<\/strong> 34G ultra-fine needle \u2192 multi-point micro-injections in the superficial dermis of fine line areas \u2192 0.01-0.02ml per point \u2192 total 0.5-1.0ml per side \u2192 gentle pressure after injection<\/li>\n<li><strong>Post-treatment soothing and assessment (3 min):<\/strong> Cold compress \u2192 confirm no abnormal reaction \u2192 check injection evenness<\/li>\n<li><strong>Post-care instructions (2 min):<\/strong> Precautions (avoid rubbing eyes and makeup for 24 hours, avoid strenuous exercise for 48 hours, avoid high-heat and acid-containing eye skincare for 1 week, strict sun protection) \u2192 schedule 4-week follow-up for second session<\/li>\n<\/ol>\n<p>The Rejuran PDRN periocular injection takes about 20 minutes, with mild redness and pinholes subsiding in 1-2 days. 3 sessions (4 weeks apart) achieve optimal results. Located 3 minutes from Gangnam Station Exit 10, with seamless English and Chinese consultation.<\/p>\n<h2>Frequently Asked Questions<\/h2>\n<div class=\"faq-item\">\n<div class=\"faq-q\">How long do Rejuran PDRN eye area results last? How many sessions are needed?<\/div>\n<div class=\"faq-a\">PDRN eye area results have two phases: (1) Initial effect \u2014 collagen begins regenerating 2-4 weeks after injection, fine lines gradually improve. (2) Cumulative effect \u2014 3 sessions (4 weeks apart) achieve optimal results, lasting 6-9 months. Recommendation: 3 intensive sessions initially, then 1 maintenance every 6-9 months. Factors: (1) Age \u2014 younger patients have stronger collagen regeneration, longer-lasting. (2) Sun protection \u2014 UV accelerates collagen loss; strict protection extends results. (3) Skincare \u2014 peptide and vitamin C eye creams enhance results. Rappoel recommends 3 sessions as a complete course, with maintenance when results diminish.<\/div>\n<\/div>\n<div class=\"faq-item\">\n<div class=\"faq-q\">What’s the difference between PDRN and HA eye area filler? How to choose?<\/div>\n<div class=\"faq-a\">They solve different problems: (1) PDRN \u2014 ‘biological regeneration,’ injected into the dermis to activate collagen synthesis, improving skin texture (fine lines, roughness, dullness). Results are progressive (2-4 weeks), suitable for periocular fine lines and texture. (2) HA \u2014 ‘physical filling,’ injected into hollow areas to restore volume, addressing structural hollowness (tear trough, hollowness). Results are instant, suitable for tear trough and eye-area hollowness. Choosing: (1) Fine lines primarily \u2192 PDRN. (2) Tear trough hollowness primarily \u2192 HA. (3) Both fine lines and hollowness \u2192 PDRN + HA combined \u2014 PDRN improves texture, HA fills hollowness, most complete results. Rappoel assesses during consultation.<\/div>\n<\/div>\n<div class=\"faq-item\">\n<div class=\"faq-q\">Is PDRN eye area injection painful? Will it swell?<\/div>\n<div class=\"faq-a\">Pain is minimal \u2014 Rappoel’s pain control: (1) 34G ultra-fine needle \u2014 thinner than hair, feels like a mosquito bite. (2) Topical anesthesia \u2014 lidocaine cream for 15 minutes, greatly reducing discomfort. (3) Micro-injection \u2014 only 0.01-0.02ml per point, minimal pressure. Post-treatment reactions: (1) Redness \u2014 mild injection-site redness, 2-4 hours. (2) Pinholes \u2014 fine pinholes close in 1-2 days, barely visible. (3) Swelling \u2014 thin eye skin may have mild swelling, 1-2 days. (4) Bruising \u2014 some have mild bruising (especially under-eye), 3-5 days. Overall recovery 1-2 days, normal work the next day (minimal concealer sufficient).<\/div>\n<\/div>\n<div class=\"faq-item\">\n<div class=\"faq-q\">What’s the difference between PDRN and Coretox for crow’s feet? Can they be done together?<\/div>\n<div class=\"faq-a\">They solve different problems: (1) Coretox \u2014 relaxes the orbicularis oculi, improving ‘dynamic lines’ (crow’s feet when smiling). Fast onset (2-3 days), lasting 3-5 months. (2) PDRN \u2014 stimulates collagen regeneration, improving ‘static lines’ (visible without expression) and skin texture. Progressive results (2-4 weeks), lasting 6-9 months. Combined treatment is optimal: Coretox controls dynamic lines (preventing expression from further deepening static lines) + PDRN regenerates skin to improve static lines \u2014 synergistic, comprehensive dynamic + static improvement. Rappoel recommends: patients with significant crow’s feet should get Coretox first to relax muscles, then PDRN 2 weeks later to regenerate skin \u2014 control the ‘external cause’ (muscle pulling) first, then repair the ‘internal cause’ (collagen loss).<\/div>\n<\/div>\n<div class=\"faq-item\">\n<div class=\"faq-q\">What is PDRN? Is it safe? What are the side effects?<\/div>\n<div class=\"faq-a\">PDRN (Polydeoxyribonucleotide) is polydeoxyribonucleotide extracted from salmon milt \u2014 a highly purified DNA fragment. Safety: (1) Extremely high biocompatibility \u2014 salmon DNA is structurally similar to human DNA, causing no rejection. (2) Clinically validated \u2014 PDRN has over 10 years of clinical use in Korea and Europe with a good safety record. (3) Purification \u2014 multiple purification steps remove proteins and impurities, retaining only active DNA fragments. Common reactions: mild injection-site redness, swelling, pinholes (1-2 days). Rare: mild bruising (3-5 days). Severe side effects are extremely rare. Not suitable: those with fish allergy, pregnancy\/breastfeeding, severe autoimmune disease. Rappoel confirms allergy history and health status before injection.<\/div>\n<\/div>\n<div class=\"cta\">\n<h3>Periocular fine lines making your eyes look tired? Rappoel Rejuran PDRN eye regeneration \u2014 20 minutes for firm, bright eye area!<\/h3>\n<p>\ud83d\udccd 77, Seocho-daero, Seocho-gu, Seoul, South Korea<\/p>\n<p>\ud83d\udd50 Mon\u2013Fri 10:00\u201319:00 \u00b7 Sat 10:00\u201317:00<\/p>\n<p>\ud83d\udcac WeChat Main: rappoelkr | WeChat Backup: rappoelkr2 | LINE: rappoelkr<\/p>\n<p style=\"margin-top:16px;font-size:13px;color:#8B7355;\">Scan to connect with us<\/p>\n<div style=\"display:flex;justify-content:center;gap:16px;flex-wrap:wrap;margin-top:10px;\">\n<div style=\"text-align:center;\">\n <img decoding=\"async\" src=\"https:\/\/rappoel-clinic.com\/wp-content\/uploads\/2026\/04\/Rappoel\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff08\u4e3b\u53f7\uff09-1.png\" alt=\"WeChat Main QR Code\" style=\"width:120px;height:120px;border-radius:6px;\" \/><\/p>\n<p style=\"font-size:11px;color:#6b5240;margin-top:4px;\">WeChat (Main)<\/p>\n<\/p><\/div>\n<div style=\"text-align:center;\">\n <img decoding=\"async\" src=\"https:\/\/rappoel-clinic.com\/wp-content\/uploads\/2026\/04\/Rappoel\u5fae\u4fe1\u4e8c\u7ef4\u7801\uff08\u5907\u7528\u53f7\uff09-1.png\" alt=\"WeChat Backup QR Code\" style=\"width:120px;height:120px;border-radius:6px;\" \/><\/p>\n<p style=\"font-size:11px;color:#6b5240;margin-top:4px;\">WeChat (Backup)<\/p>\n<\/p><\/div>\n<div style=\"text-align:center;\">\n <img decoding=\"async\" src=\"https:\/\/rappoel-clinic.com\/wp-content\/uploads\/2026\/04\/Line\u4e8c\u7ef4\u7801-1.jpg\" alt=\"LINE QR Code\" style=\"width:120px;height:120px;border-radius:6px;\" \/><\/p>\n<p style=\"font-size:11px;color:#6b5240;margin-top:4px;\">LINE<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<\/div>\n<\/div>\n<p><\/body><br \/>\n<\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Eye area fine lines making your eyes look tired and aged? 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